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نمایش مقاله

Title:

Altered Auditory Prediction Error Processing in Decompensated Tinnitus: Insights from Mismatch Negativity

Subject:

Clinical Applications of Brain Mappin

Presenter Author:
Name:	Saeid Mahmoudian

Author:
Name 1:	Saeid Mahmoudian - Corresponding - Presenter
Affiliation 1:	Associate Professor of Neuroaudiology & Auditory Neuroscience, ENT and Head & Neck Research Center, The Five Senses Health Institute, School of Medicine, Iran University of Medical Sciences,

Name 2:	Ahmad Daneshi
Affiliation 2:	ENT and Head & Neck Research Center, The Five Senses Health Institute, School of Medicine, Iran University of Medical Sciences,

Name 3:	Abdoreza Asadpour
Affiliation 3:	Sussex Neuroscience, School of Life Sciences, University of Sussex, Brighton, UK

Name 4:	Samer Mohsen
Affiliation 4:	ENT and Head & Neck Research Center, The Five Senses Health Institute, School of Medicine, Iran University of Medical Sciences,

Name 5:	Mohammad Farhadi
Affiliation 5:	ENT and Head & Neck Research Center, The Five Senses Health Institute, School of Medicine, Iran University of Medical Sciences,

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Abstract

Original Research

introduction :

Introduction While some individuals with tinnitus successfully habituate to the phantom auditory percept, others experience persistent annoyance and distress, a condition commonly referred to as decompensated tinnitus. Effective habituation depends on intact auditory sensory memory and change detection mechanisms, which enable the tinnitus signal to be processed as a predictable and non-salient stimulus. Impairments in these mechanisms may result in persistent auditory prediction errors, thereby preventing habituation. Mismatch negativity (MMN), an event-related potential elicited by deviant auditory stimuli, is a well-established neural index of sensory memory and automatic change detection. The present study aimed to compare MMN responses among compensated tinnitus, decompensated tinnitus, and normal-hearing control subjects to identify neurophysiological factors associated with tinnitus perception and failure of habituation in decompensated tinnitus.

Methods:

Methods Electroencephalographic (EEG) recordings were obtained from scalp electrodes in three groups: subjects with compensated tinnitus, subjects with decompensated tinnitus, and healthy control participants without tinnitus. MMN responses were elicited using a passive auditory oddball paradigm incorporating three types of deviants: frequency deviation, duration deviation, and silent gap deviation embedded within a standard stimulus sequence. MMN amplitude, latency, and area under the curve (AUC) were extracted and statistically compared across the three study groups.

Results:

Results The decompensated tinnitus group demonstrated significantly reduced MMN amplitude and AUC in response to higher-frequency deviants and silent gap deviants compared with both the compensated tinnitus group and the normal control group. No significant differences were observed between the compensated tinnitus and control groups for these measures. MMN latency did not show consistent group differences across the deviant types.

Conclusion:

Conclusions The findings indicate a deficit in auditory sensory memory and automatic change detection processes in individuals with decompensated tinnitus. Such impairment may lead to persistent auditory prediction errors, causing the tinnitus percept to be repeatedly detected as a novel and salient signal. This continuous salience attribution is likely mediated by activation of the brain’s salience network and may underlie the failure of habituation in decompensated tinnitus. MMN may therefore serve as a valuable neurophysiological marker for assessing tinnitus-related dysfunction and for monitoring the effectiveness of tinnitus rehabilitation and intervention strategies.

Keywords:

change detection, habituation, mismatch negativity, prediction error, sensory memory, tinnitus