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Effects of the Mind Simulation Technique on Psychological State, Craving, and Resting-State fMRI Connectivity in Substance Use Disorder: A Case Study
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1
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| Subject:
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Clinical Applications of Brain Mappin
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Presenter Author:
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| Name:
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Hamid Kamarzarin
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Author:
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| Name 1:
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Hamid Kamarzarin - Corresponding - Presenter
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| Affiliation 1:
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Head, Committee of Autism, Neuroscience and Psychiatry, Functional Neurosurgery Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran; Founder of Biological Artificial Intelligence (BAI) & Mental Simulation Method (MSM); Faculty of Psychology, Payame Noor University, Iran
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| Name 2:
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Mojtaba Bigdeli Shamloo
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Co-Founder of BAI; Neuropsychology .mind simulation founder Researcher, Iran.
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Abstract
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Original Research
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introduction :
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According to the Diagnostic and Statistical Manual of Mental Disorders (DSM-5-TR, 2022), Substance Use Disorder (SUD) is defined as a maladaptive pattern of substance use leading to clinically significant impairment or distress, characterized by impaired control, persistent craving (urge to use), and continued substance use despite negative consequences. SUD is also associated with cognitive dysfunction and deficits in executive control. Given the limitations of existing treatments, there is a need for interventions targeting psychological, cognitive, and neurobiological mechanisms. This study examined the effects of the Mind Simulation Technique (MST) on psychological state, cognition, craving, and resting-state brain connectivity.
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Methods:
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A pre–post intervention design was employed. The participant completed an eight-session MST protocol. Psychological and cognitive assessments measuring addiction-related attitudes, craving intensity (urge to use), craving-related beliefs, and cognitive regulation were administered before and after the intervention. Resting-state functional magnetic resonance imaging (rs-fMRI) was conducted at both time points, and within-subject comparisons were used to evaluate changes in functional connectivity.
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Results:
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Post-intervention findings showed reductions in craving intensity and maladaptive craving-related beliefs, along with improvements in cognitive and executive functioning. Resting-state fMRI analysis revealed increased functional connectivity within cognitive control regions, particularly involving the dorsolateral prefrontal cortex (DLPFC) and anterior cingulate cortex (ACC). In contrast, decreased connectivity was observed in reward- and salience-related regions, including the orbitofrontal cortex (OFC), amygdala, and basal ganglia.
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Conclusion:
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These findings suggest that the Mind Simulation Technique may modulate psychological state, cognition, and craving by reorganizing resting-state neural networks. MST appears to enhance top-down cognitive control while attenuating bottom-up reward-driven neural processing, supporting its potential as a complementary intervention for substance use disorder. This study is presented as a case study.
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| Attachment:
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| Keywords:
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Mind Simulation, Craving, Addiction, Resting-State fMRI, Functional Connectivity, Cognitive Intervention
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| Key message:
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