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Age-dependent effective connectivity between functionally anticorrelated networks under partial sleep deprivation
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| Subject:
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Brain Mapping Applications in Epilepsy – Across Pediatric and Adult Populations
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Presenter Author:
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| Name:
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Farnoosh Vosough
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Author:
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| Name 1:
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Farnoosh Vosough - Corresponding - Presenter
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| Affiliation 1:
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School of Medicine, Iran University of Medical Sciences, Tehran, Iran
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Abstract
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Original Research
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introduction :
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Partial sleep deprivation (PSD) is prevalent in modern societies and is associated with multiple
domains of cognitive dysfunction. Evidence suggests that the balance between the default
mode network (DMN), dorsal attention network (DAN), and salience network (SN) is crucial for
internally and externally directed cognition and may be particularly vulnerable to PSD.
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Methods:
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This study investigated effective connectivity (EC) within and between these networks and whether
these effects differ by age. Resting-state functional magnetic resonance imaging (fMRI) data
were analysed using spectral dynamic causal modeling (spDCM) with parametric empirical Bayes after a night of full sleep and following PSD in younger (20–30 years, n = 39) and older
(65–75 years, n = 34) adults.
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Results:
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Within-network analysis revealed predominantly increased DMN
connectivity in younger adults and more selective DMN reductions in older adults. The DAN was
the least affected network in the within-network analysis. Further investigation of age-dependent
effects showed relatively more PSD-related increases in EC in the older group than in the
younger group, particularly within DAN and SN pathways. At the between-network level,
younger and older adults showed a broadly similar organization at baseline, but this pattern
changed differentially after PSD. In younger adults, PSD amplified the excitatory influence of the
SN on the DMN and its inhibitory influence on the DAN. PSD also increased DAN-to-DMN connectivity, whereas older adults showed a partly reversed pattern, with a shift toward
increased SN-to-DAN influence.
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Conclusion:
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These findings emphasize the age-dependent reorganization of directed relationships within large-scale networks after PSD.
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| Attachment:
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| Keywords:
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Sleep deprivation, dynamic causal modelling, resting-state fMRI, intrinsic brain networks
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| Key message:
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